These saints  were martyred by the Turks on Bright Tuesday (April 9, 1463) ten years after the  Fall of Constantinople. For nearly 500 years, they were forgotten by the people  of Lesbos, but "the righteous Judge... opened the things that were hid" (2 Macc.  12:41). 
For centuries the people of Lesbos would go on Bright Tuesday to  the ruins of a monastery near Thermi, a village northwest of the capital,  Mytilene. As time passed, however, no one could remember the reason for the  annual pilgrimage. There was a vague recollection that once there had been a  monastery on that spot, and that the monks had been killed by the Turks.  
In 1959, a pious man named Angelos Rallis decided to build a chapel near  the ruins of the monastery. On July 3 of that year, workmen discovered the  relics of St Raphael while clearing the ground. 
[After the discovery of the  grave, amazing phenomena started to occur. The bones were put in a sack by a Mr  Doukas Tsolakis. He was in charge of the excavations. He could not lift the sack  up due to the excessive weight. Noises were heard from the bones.They were also  producing a fragrant incense. One of the workers, a Mr Leonidas Sideras kicked  the sack and his leg went numb. Tsolakis' hand remained motionless. He could not  lift the sack.The priest was asked to do a Trisagion-a prayer for the departed.  The night before he was due to conduct the service, he was wondering what name  he should use. During the night Saint Raphael appeared to the Priest. He told him  who he was, and that he was born on the island of Ithaka. 
(http://www.ayiosnektarios.co.uk/straphael/straphael.htm)]
Soon, the saints began appearing  to various inhabitants of Lesbos and revealed the details of their lives and  martyrdom. These accounts form the basis of Photios Kontoglou's 1962 book A  GREAT SIGN (in Greek).
   
St Raphael was born on the island of Ithaka  around 1410, and was raised by pious parents. His baptismal name was George, but  he was named Raphael when he became a monk. He was ordained to the holy  priesthood, and later attained the offices of Archimandrite and Chancellor.  
[He previously also served as parish priest in the  church of St Demetrios of Loumbardiaris in Athens. (http://www.ayiosnektarios.co.uk/straphael/straphael.htm)]
   
[Once when St. Raphael travelled to France,   he met St Nicholas at Morlaix. Nicholas was from a wealthy family. He was a  young student from Thessalonika studying at a French university. Nicholas was  moved by the teaching of St. Raphael and they became firm friends and his disciple. (http://www.ayiosnektarios.co.uk/straphael/straphael.htm)]
In 1453, St Raphael was living in Macedonia with his fellow monastic,  the deacon Nicholas, a native of Thessalonica. 
[
For an account of how Sts. Raphael and Nicholas fled Constantinople in defence of Orthodoxy, see: http://full-of-grace-and-truth.blogspot.com/2009/08/st-raphael-of-lesvos-and-defense-of.html]
In 1454, the Turks invaded  Thrace, so the two monks fled to the island of Lesbos. They settled in the  Monastery of the Nativity of the Theotokos near Thermi, where St Raphael became  the igumen. 
[The monastery that they found at Thermi was a ruined Byzantine monastery, destroyed after a raid by pirates in 1235AD. Later through additional revelations, some of the Holy Relics of the martyred nuns were discovered, including St. Olympia the Abbess 
(http://lesvosisland.webs.com/monasterieschurches.htm)]
The wondrous tomb of St. Raphael in his Monastery, as it appears today. Note that the Saints' tombs and many other treasures of the monastery, were found through divine revelation as to their exact location, 500 years after their martyrdom. This is truly vivid proof of Christ's Resurrection. (http://www.agios-rafael.org/images/27-naos.jpg) 
   
In the spring of 1463, the Turks raided the monastery and  captured the monks. They were tortured from Holy Thursday until Bright Tuesday.  St Raphael was tied to a tree, and the ferocious Turks sawed through his jaw,  killing him. St Nicholas was also tortured, and he died while witnessing his  Elder's martyrdom. He appeared to people and indicated the spot where his relics  were uncovered on June 13, 1960. 
   
The Martyrdom of St. Raphael and St. Nicholas the New Righteous Martyrs of Lesvos (unknown source)
   
St Irene was the twelve-year-old  daughter of the village mayor, Basil. She and her family had come to the  monastery to warn the monks of the invasion. The cruel Hagarenes cut off one of  her arms and threw it down in front of her parents. Then the pure virgin was  placed in a large earthen cask and a fire was lit under it, suffocating her  within. These torments took place before the eyes of her parents, who were also  put to death. Her grave and the earthen cask were found on May 12, 1961 after  Sts Raphael, Nicholas and Irene had appeared to people and told them where to  look.
The Martyrdom of St. Irene the Virgin Martyr of Lesvos (unknown source)   
   
Others who received the crown of martyrdom on that day were Basil  and Maria, the parents of St Irene; Theodore, the village teacher; and Eleni,  the fifteen-year-old cousin of St Irene. 
   
The saints appeared separately  and together, telling people that they wished to be remembered. They asked that  their icon be painted, that a church service be composed for them, and they  indicated the place where their holy relics could be found. Based on the  descriptions of those who had seen the saints, the master iconographer Photios  Kontoglou painted their icon. The ever-memorable Father Gerasimos of Little St  Anne Skete on Mt. Athos composed their church service. 
The Burial of St. Raphael of Lesvos (unknown source)
   
Many miracles  have taken place on Lesbos, and throughout the world. The saints hasten to help  those who invoke them, healing the sick, consoling the sorrowful, granting  relief from pain, and bringing many unbelievers and impious individuals back to  the Church. 
   
St Raphael is tall, middle-aged, and has a beard of moderate  length. His hair is black with some grey in it. His face is majestic,  expressive, and filled with heavenly grace. St Nicholas is short and thin, with  a small blond beard. He stands before St Raphael with great respect. St Irene  usually appears with a long yellow dress reaching to her feet. Her blonde hair  is divided into two braids which rest on either side of her chest. 
   
The first appearance of St. Raphael (source) 
   
Sts  Raphael, Nicholas, and Irene (and those with them) are also commemorated on  Bright Tuesday. Dr. Constantine Cavarnos has given a detailed account of their  life, miracles, and spiritual counsels in Volume 10 of his inspirational series  MODERN ORTHODOX SAINTS (Belmont, MA, 1990).
(http://ocafs.oca.org/FeastSaintsViewer.asp?SID=4&ID=1&FSID=29)
   
   
Excerpt from the teachings of St. Raphael given to various individuals through his appearances
1.Christ and We
Only where Christ dwells is there blessedness. Where  Christ blesses there is heavenly repose. Where Christ turns His benveolent gaze  there is inexpressible true joy. Christ, with His unceasing love for us and His  great humility, loves us and invisibly reproves us and reminds us through His  miracles that there is life in the Kingdom of Heaven.  
2. The Path of Christ
The path of Christ is somewhat difficult, but with  patience, will, and humility one makes progress... It involves tribulation and  suffering, without which it is not possible for one to find the path open for  the benefit of his soul.  
3. Repentance and Regeneration
When a person is in a state of bondage to  sin and has as an obstacle sadness and cannot concentrate, it means that he is  without the regeneration of our Savior Jesus Christ and is far from Him.  
But when a man "comes to himself" and feels that his soul is far from God and  becomes aware of his sinfulness, and with tears of repentance entreats our  Heavenly Father to forgive him and bring him back to the heavenly joy of our  Christ, then the regeneration of his soul takes place.  
4. Care of the soul
When a Christian exercises watchful care, he heals his  soul and does not allow it to be lost....Do not let your soul go astray in  matter, in the corruptible things of the world. Life has no value if we do not  take care of the soul. Therefore, do not let yourselves go astray and lose your  soul Read carefully the Gospels, because these were written with the Grace and  the glory of God, to be read by the faithful that their life might shine.  
   
The finding of the Holy Relic of St. Raphael, on July 3rd, 1959 (source) 
   
On days when a Saint is celebrated, Christians ought to pray more ardently,  with contrition and love, and entreat the Saint to intercede with God for the  salvation of their soul. The feast day of every Saint is for Christians a  serious reminder of the great sufferings which the Saints experienced for the  sake of Christ's faith. They were glorified by God and with glory they received  a place in the Kingdom of Heaven.  
Let us then honor the Saints and invoke their help, in order that they might  strengthen us in our prayer. And we may rest assured that our prayer will be  listened to by God.  
A guileless spirit is one which has no badness within it. Badness is a  characteristic of the evil one, who seeks by means of wickedness to divert man  from the path of virtue and from God. Consequently, great carefulness and effort  are needed in order that there might reign in the soul a guileless and pure  spirit.  
How much care do people exercise in order to save their soul? What medicines  do they use in order to protect it from the microbes of sin which threaten and  attact it? And yet, the Lord has indicated the medicines: love, warm prayer, and  humility. They must employ all of them, seeking at the same time the help of  God, through which alone can the soul be regenerated and be freed from the  microbes of sin...Sin must be banished from the soul: greed, rapacity,  impatience, improper imagination.  
Examine your self and strive to adorn it with love, humility, compassion and  hope. Seek the regeneration of your soul, enlightened by the voice of the Gospel  and helped by God. With fear and love for the Heavenly Father, proceed to sow  the seeds of God's word on good soil. Cultivate the talent given by Christ for  the salvation of your soul. 
(http://www.serfes.org/writtings/straphael.htm)
   
   
Apolytikion in honor of all three Saints: RAPAHEL, NICHOLAS  AND IRENE in the Fourth Tone
Having contended on Lesvos for the sake for Christ God, you  have sanctified the island since the discovery of your sacred relics, O blessed  ones; wherefore we honor you, O God-bearing Raphael, together with Nicholas and  virgin Irene, as our divine protectors and intercessors with the Lord.  
Kontakion in the Fourth Tone
Let all of us honor as our protectors and  miracle-workers the holy Martyrs who manifestly contended for Christ, whose  sacred relics were hidden under the earth for many years, and who have  manifested themselves to us in wondrous ways: Raphael, Nicholas, and divine  Irene, as well as those who contended with them in a godly-minded manner.  
Megalynarion
Let us honor with hymns the Hosiomartyrs  of Christ, divine Raphael and venerable Nicholas, together with Irene, the  guardians of Lesvos, for helping us.
   
   
Christ is risen from the dead, by death trampling upon death, and to those in the tombs granting life! 
Truly the Lord is risen!